![]() This suggests that the mechanism by which OdDHL might protect against diabetes may not be simply as a result of selective suppression of Th1 activity. Subsequently, however, in vitro and in vivo studies examining responses in BALB/c and C57BL/6 mice have demonstrated that OdDHL can modulate either Th1 or Th2 cell responses, depending on the underlying cell bias of the different strains ( 21). Therefore, one possible mechanism by which OdDHL might inhibit diabetes development might be as a result of skewing the immune response toward a Th2 response. Initial in vitro studies suggested that OdDHL had a pronounced inhibitory effect on the production of cytokines associated with a proinflammatory Th1 response while permitting a Th2 response ( 24). The natural synthetic version of a quorum-sensing signal molecule from Pseudomonas aeruginosa, N-3-(oxododecanoyl)- l-homoserine lactone (OdDHL), has been shown to delay the onset and reduce the final incidence of diabetes in female NOD mice ( 17). ![]()
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